Advancement of regulating cellular signaling pathways in NSCLC target therapy via nanodrug

Wenqiang Li; Mei Li; Qian Huang; Xiaoyu He; Chen Shen; Xiaoming Hou; Fulai Xue; Zhiping Deng; Yao Luo

doi:10.3389/fchem.2023.1251986

Advancement of regulating cellular signaling pathways in NSCLC target therapy via nanodrug

Front Chem. 2023 Sep 7:11:1251986. doi: 10.3389/fchem.2023.1251986. eCollection 2023.

Authors

Wenqiang Li^#¹, Mei Li^#², Qian Huang³, Xiaoyu He³, Chen Shen², Xiaoming Hou², Fulai Xue², Zhiping Deng¹, Yao Luo^{1

2}

Affiliations

¹ Zigong First People's Hospital, Zigong, Sichuan, China.
² West China Hospital, Sichuan University, Chengdu, Sichuan, China.
³ Sichuan North Medical College, Nanchong, Sichuan, China.

^# Contributed equally.

Abstract

Lung cancer (LC) is one of the leading causes of high cancer-associated mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common type of LC. The mechanisms of NSCLC evolution involve the alterations of multiple complex signaling pathways. Even with advances in biological understanding, early diagnosis, therapy, and mechanisms of drug resistance, many dilemmas still need to face in NSCLC treatments. However, many efforts have been made to explore the pathological changes of tumor cells based on specific molecular signals for drug therapy and targeted delivery. Nano-delivery has great potential in the diagnosis and treatment of tumors. In recent years, many studies have focused on different combinations of drugs and nanoparticles (NPs) to constitute nano-based drug delivery systems (NDDS), which deliver drugs regulating specific molecular signaling pathways in tumor cells, and most of them have positive implications. This review summarized the recent advances of therapeutic targets discovered in signaling pathways in NSCLC as well as the related NDDS, and presented the future prospects and challenges.

Keywords: drug resistance; nanodrug; non-small cell lung cancer; signaling pathways; targeted therapy.

Publication types

Review

Grants and funding

This work was funded by the Zigong Academy of Medical Sciences 2022, Nos ZGYKY22KF008, ZGYKY22KF009, and ZGYKY22KF005; the National Natural Science Foundation of China, No. 82003262; the Key R&D Program of Sichuan Provincial Department of Science and Technology (Major Science and Technology Project), No. 2022YFS0095; China Postdoctoral Science Foundation, Nos 2019TQ0221 and 2019M663517; Post-Doctor Research Project, West China Hospital, Sichuan University, Nos 2019HXBH059 and 2021HXBH009; Sichuan University Postdoctoral Interdisciplinary Innovation Fund.