A High intensity Interval training (running and swimming) and resistance training intervention on heart rate variability and the selected biochemical factors in boys with type 1 diabetes

Hossein Saki; Farzad Nazem; Farnaz Fariba; Reza Sheikhsharbafan

doi:10.1016/j.diabres.2023.110915

A High intensity Interval training (running and swimming) and resistance training intervention on heart rate variability and the selected biochemical factors in boys with type 1 diabetes

Diabetes Res Clin Pract. 2023 Oct:204:110915. doi: 10.1016/j.diabres.2023.110915. Epub 2023 Sep 22.

Authors

Hossein Saki¹, Farzad Nazem², Farnaz Fariba³, Reza Sheikhsharbafan³

Affiliations

¹ Department of Exercise Physiology, Sports Science Faculty, Hamadan Bu Ali Sina University, Iran.
² Department of Exercise Physiology, Sports Science Faculty, Hamadan Bu Ali Sina University, Iran. Electronic address: f.nazem@basu.ac.ir.
³ Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

PMID: 37742805
DOI: 10.1016/j.diabres.2023.110915

Abstract

Objective: The purpose of this research is to investigate the effect of High Intensity Interval Training and Resistance training (HIITR) on heart rate variability (HRV), blood glucose, and plasma biomarkers levels in adolescents with type 1 diabetes (T1D).

Research design and methods: 24 boys with T1D (FBS: 274.66 ± 52.99, age: 15.2 ± 1.78 years, and BMI = 19.61 ± 1.11) and 12 healthy boys (FBS: 92.75 ± 5.22, age: 15.08 ± 1.67 years, and BMI = 20.26 ± 2.66) were divided into three groups: Diabetes Training (DT, n = 12), Diabetes Control (DC, n = 12), and Healthy Control (HC, n = 12). HRV (24 h) was computed in time and frequency domains, anthropometric, biochemical parameters at rest, and aerobic capacity (VO_2peak) obtained during a graded exercise testing (GXT). All variables were evaluated at the baseline and following 12 weeks of exercise training, done 3 days weekly. The statistical method used for data analysis was analysis of covariance (ANCOVA) test.

Results: HRV, Hemoglobin A1c (HbA1c) and Fasting blood sugar (FBS), VO_2peak, norepinephrine (NEP), and HDL-C indicated significant differences between both T1D groups compared to HC at baseline (p < 0.001). BMI, LDL-C, TC, and TG parameters were similar in all groups. HRV parameters, VO_2peak and HDL-C, and NEP were significantly improved by exercise training, and HbA1c and FBS levels were significantly reduced (p < 0.001). There is a negative and significant correlation between LF/HF Ratio Difference (post-test minus pre-test) and VO2Peak Difference variables (post-test minus pre-test) (p < 0.001).

Conclusions: The present study suggests the importance of early screening for CVD risk factors in adolescent males with T1D. Also, it was revealed HIITR training compared to other training patterns, and cardiovascular health improves via enhancement of autonomic modulation, VO_2peak, plasma lipids, and catecholamine levels.

Keywords: Blood glucose; Catecholamines; Heart rate variability; Interval aerobic training; Type 1 diabetes.

MeSH terms

Adolescent
Diabetes Mellitus, Type 1*
Glycated Hemoglobin
Heart Rate / physiology
High-Intensity Interval Training*
Humans
Male
Resistance Training*
Running*
Swimming

Substances

Glycated Hemoglobin