Biomaterials-enhanced bioactive agents to efficiently block spinal metastases of cancers

Shixian Liu; Zhonghan Wang; Qi Wei; Xuefeng Duan; Yang Liu; Minfei Wu; Jianxun Ding

doi:10.1016/j.jconrel.2023.09.039

Biomaterials-enhanced bioactive agents to efficiently block spinal metastases of cancers

J Control Release. 2023 Nov:363:721-732. doi: 10.1016/j.jconrel.2023.09.039. Epub 2023 Oct 18.

Authors

Shixian Liu¹, Zhonghan Wang², Qi Wei³, Xuefeng Duan¹, Yang Liu⁴, Minfei Wu⁵, Jianxun Ding⁶

Affiliations

¹ Department of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China.
² Department of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, PR China.
³ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China; Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, PR China.
⁴ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China.
⁵ Department of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, PR China. Electronic address: wumf@jlu.edu.cn.
⁶ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China; Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, 388 Yuhangtang Road, Hangzhou 310058, PR China. Electronic address: jxding@ciac.ac.cn.

PMID: 37741462
DOI: 10.1016/j.jconrel.2023.09.039

Abstract

The spine is the most common site of bone metastases, as 20%-40% of cancer patients suffer from spinal metastases. Treatments for spinal metastases are scarce and palliative, primarily aiming at relieving bone pain and preserving neurological function. The bioactive agents-mediated therapies are the most effective modalities for treating spinal metastases because they achieve systematic and specific tumor regression. However, the clinical applications of some bioactive agents are limited due to the lack of targeting capabilities, severe side effects, and vulnerability of drug resistance. Fortunately, advanced biomaterials have been developed as excipients to enhance these treatments, including chemotherapy, phototherapy, magnetic hyperthermia therapy, and combination therapy, by improving tumor targeting and enabling sustaining and stimuli-responsive release of various therapeutic agents. Herein, the review summarizes the development of biomaterials-mediated bioactive agents for enhanced treatments of spinal metastases and predicts future research trends.

Keywords: Bioactive material; Chemotherapy; Combination therapy; Inhibition of spinal metastases; Magnetic hyperthermia therapy; Phototherapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / therapeutic use
Humans
Phototherapy
Spinal Neoplasms* / drug therapy
Spinal Neoplasms* / secondary

Substances

Biocompatible Materials