Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors

Thamara Nishida Xavier da Silva; José Pedro Friedmann Angeli

doi:10.1016/j.chembiol.2023.08.015

Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors

Cell Chem Biol. 2023 Sep 21;30(9):1006-1008. doi: 10.1016/j.chembiol.2023.08.015.

Authors

Thamara Nishida Xavier da Silva¹, José Pedro Friedmann Angeli²

Affiliations

¹ Rudolf Virchow Center for Integrative and Translational Bioimaging, Chair of Translational Cell Biology, University of Wuerzburg, 97080 Wuerzburg, Germany.
² Rudolf Virchow Center for Integrative and Translational Bioimaging, Chair of Translational Cell Biology, University of Wuerzburg, 97080 Wuerzburg, Germany. Electronic address: pedro.angeli@virchow.uni-wuerzburg.de.

PMID: 37738951
DOI: 10.1016/j.chembiol.2023.08.015

Abstract

The report of heightened lipid peroxidation has shone a spotlight on vulnerabilities within challenging cancers. In this context, FSP1 emerges as a pivotal regulator, actively countering the destructive effects of lipid peroxidation. In a groundbreaking development detailed in the latest issue of Cell Chemical Biology, Hendricks et al. unveil FSEN1, a potent inhibitor of FSP1. The discovery of FSEN1 holds tremendous promise as it synergizes with GPX4 inhibitors, in addition to several FDA-approved drugs, amplifying their capacity to induce ferroptosis in resistant cancer cells. This represents a significant stride towards ferroptosis-based strategies in preclinical settings.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Ferroptosis*
Lipid Peroxidation