Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation

Zachary Corey; Elyse Schechter; Raphael A Nemenoff

doi:10.1016/j.chembiol.2023.08.013

Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation

Cell Chem Biol. 2023 Sep 21;30(9):1004-1006. doi: 10.1016/j.chembiol.2023.08.013.

Authors

Zachary Corey¹, Elyse Schechter¹, Raphael A Nemenoff²

Affiliations

¹ Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
² Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: raphael.nemenoff@cuanschutz.edu.

PMID: 37738950
DOI: 10.1016/j.chembiol.2023.08.013

Abstract

MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al.¹ report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy.

Publication types

Comment

MeSH terms

Antigen Presentation
Fatty Acid Synthases
Immunotherapy
Lipid Metabolism*
Neoplasms*
Seat Belts

Substances

Fatty Acid Synthases