Physical activity interventions for cancer-related fatigue: A scoping review of randomized controlled trials from a Nursing Science Precision Health Model perspective

Pamela K Ginex; Sylvia K Wood; Kapeena Sivakumaran; Ifeoluwa Babatunde; Tiffany Yu; Karen DiValerio Gibbs; Rebecca L Morgan

doi:10.1016/j.outlook.2023.102052

Physical activity interventions for cancer-related fatigue: A scoping review of randomized controlled trials from a Nursing Science Precision Health Model perspective

Nurs Outlook. 2023 Nov-Dec;71(6):102052. doi: 10.1016/j.outlook.2023.102052. Epub 2023 Sep 20.

Authors

Pamela K Ginex¹, Sylvia K Wood², Kapeena Sivakumaran³, Ifeoluwa Babatunde⁴, Tiffany Yu⁵, Karen DiValerio Gibbs⁶, Rebecca L Morgan⁷

Affiliations

¹ School of Nursing, Stony Brook University School of Nursing, Stony Brook, NY. Electronic address: Pamela.ginex@stonybrookmedicine.edu.
² School of Nursing, Stony Brook University School of Nursing, Stony Brook, NY.
³ Evidence Foundation, Cleveland, OH.
⁴ Evidence Foundation, Cleveland, OH; School of Medicine, Case Western Reserve University, Cleveland, OH.
⁵ Evidence Foundation, Cleveland, OH; Faculty of Health Sciences, McMaster University, Hamilton, ON.
⁶ Hematology & Oncology, Baylor College of Medicine, Houston, TX.
⁷ Evidence Foundation, Cleveland, OH; School of Medicine, Case Western Reserve University, Cleveland, OH; Faculty of Health Sciences, McMaster University, Hamilton, ON.

PMID: 37738805
DOI: 10.1016/j.outlook.2023.102052

Abstract

Background: The Nursing Science Precision Health (NSPH) Model has the potential to guide research on the development, testing, and targeting of interventions.

Purpose: This scoping review examines the relationship between physical activity (PA) and cancer-related fatigue (CRF) within the context of the NSPH Model.

Methods: The Joanna Briggs Institute scoping review methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guided this review. We included randomized controlled trials in people with cancer that investigated PA interventions and measured change in CRF as an outcome.

Discussion: A total of 181 studies met the eligibility criteria. Over 20 different instruments were used to measure CRF. The most common PA interventions were strength training (48%), walking (36%), cycling (26%), and yoga (15%). A limited number of studies reported phenotypic characteristics (32/181, 17%) or biomarkers (31/181, 17%) associated with CRF.

Conclusion: This scoping review identified the body of existing research exploring CRF and PA from a precision health perspective.

Keywords: Cancer-related fatigue; Nursing; Physical activity; Precision health.

Publication types

Review

MeSH terms

Exercise
Fatigue / etiology
Fatigue / prevention & control
Humans
Neoplasms* / complications
Precision Medicine*
Quality of Life
Randomized Controlled Trials as Topic