Bimetallic CuFe Prussian blue analogue cubes enhanced luminol chemiluminesence and its application

Zixin Yang; Mengling Song; Yang Chen; Funan Chen

doi:10.1016/j.saa.2023.123421

Bimetallic CuFe Prussian blue analogue cubes enhanced luminol chemiluminesence and its application

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 5:304:123421. doi: 10.1016/j.saa.2023.123421. Epub 2023 Sep 16.

Authors

Zixin Yang¹, Mengling Song¹, Yang Chen¹, Funan Chen²

Affiliations

¹ School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
² School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: chenfn@swu.edu.cn.

PMID: 37738766
DOI: 10.1016/j.saa.2023.123421

Abstract

In this paper, bimetallic CuFe Prussian blue analogue (CuFe PBA) was discovered to have oxidase-like activity. Luminol can be oxidized under alkaline conditions without adding other oxidants. The chemiluminescence (CL) intensity produced is more than 1000 times that of the original luminol-NaOH system. Thus, a novel luminol-NaOH-CuFe PBA CL sensor was constructed. The CL intensity of the system would drastically decrease with the addition of uric acid (UA), it served as the foundation for the creation of an enzyme-free CL sensor for the determination of UA. The CL signal intensity of the system showed a linear connection with the square of the UA concentration in the range of 0.25 to 0.45 mmol·L^-1, and the limits of detection was 0.10 mmol·L^-1. This system could be used to construct an efficient CL sensor for the detection of UA in human serum.

Keywords: Chemiluminescence; CuFe Prussian blue analogue; Luminol; Oxidase-like activity; Uric acid detection.