In Acute Severe Ulcerative Colitis Patients Who Receive Rescue Therapy, Prior Maintenance Therapy and Day 3 C-Reactive Protein After Rescue Therapy Are Associated With 12-Month Colectomy Risk

Jared A Sninsky; Ana-Maria Staicu; Edward L Barnes

doi:10.1093/ibd/izad215

In Acute Severe Ulcerative Colitis Patients Who Receive Rescue Therapy, Prior Maintenance Therapy and Day 3 C-Reactive Protein After Rescue Therapy Are Associated With 12-Month Colectomy Risk

Inflamm Bowel Dis. 2023 Sep 21:izad215. doi: 10.1093/ibd/izad215. Online ahead of print.

Authors

Jared A Sninsky^{1

2}, Ana-Maria Staicu³, Edward L Barnes¹

Affiliations

¹ Center for Gastrointestinal Disease and Biology, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
² Division of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
³ Department of Statistics, North Carolina State University, Raleigh, NC, USA.

PMID: 37738577
DOI: 10.1093/ibd/izad215

No abstract available

Keywords: C-reactive protein; acute severe ulcerative colitis (ASUC); colectomy; rescue therapy.

Plain language summary

In steroid-refractory patients with acute severe ulcerative colitis, the number of advanced therapies prior to admission and day 3 C-reactive protein post–rescue therapy is associated with a higher risk of colectomy within 12 months.

Grants and funding

T32 DK007634/NH/NIH HHS/United States