Effects of smoking on sleep architecture and ventilatory parameters including apneas: Results of the Tab-OSA study

Sibylle Mauries; Léa Bertrand; Justine Frija-Masson; Hélène Benzaquen; Sophie Kalamarides; Karine Sauvage; Michel Lejoyeux; Marie-Pia d'Ortho; Pierre A Geoffroy

doi:10.1016/j.sleepx.2023.100085

Effects of smoking on sleep architecture and ventilatory parameters including apneas: Results of the Tab-OSA study

Sleep Med X. 2023 Sep 7:6:100085. doi: 10.1016/j.sleepx.2023.100085. eCollection 2023 Dec 15.

Authors

Sibylle Mauries¹, Léa Bertrand¹, Justine Frija-Masson^{2

3}, Hélène Benzaquen³, Sophie Kalamarides⁴, Karine Sauvage¹, Michel Lejoyeux^{1

5}, Marie-Pia d'Ortho^{2

3}, Pierre A Geoffroy^{1

5

2

6

4}

Affiliations

¹ Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, 46 rue Henri Huchard, 75018, Paris, France.
² Université de Paris, NeuroDiderot, Inserm, U1141, 48 boulevard Sérurier, 75019, Paris, France.
³ Explorations Fonctionnelles et Centre du Sommeil- Département de Physiologie Clinique, Assistance Publique des Hôpitaux de Paris, GHU Paris Nord, DMU DREAM, Hôpital Bichat, 46 rue Henri Huchard, 75018, Paris, France.
⁴ Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Beaujon, 100 boulevard Général Leclerc, 92110, Clichy, France.
⁵ GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014, Paris, France.
⁶ CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, 5 rue Blaise Pascal, 67000, Strasbourg, France.

Abstract

Background: The interaction between smoking and sleep seems appears to be bidirectional, but few studies evaluated the impact of smoking and its cessation on objective sleep parameters. In this context, this new study aimed to assess the impact of smoking and its cessation on sleep architecture and on ventilatory sleep parameters, particularly the presence of sleep apnea syndrome (apnea-hypopnea index (AHI)≥15). Methods: Patients hospitalized for polysomnographic sleep exploration were compared according to their smoking status: active smokers (AS), former smokers (FS), non-smokers (NoNi). Psychiatric and non-psychiatric co-morbidities and treatment or substance use were taken into account in the analyses.

Results: A total of 170 participants were included (N = 37 FS, 39 AS, 86 NoNi). A significant decrease in the mean nocturnal O₂ saturation was observed for FS and AS compared to NoNi. No differences were found regarding AHI. Regarding sleep architecture, we observed a significant decrease in the slow wave sleep duration for AS compared to NoNi, and interestingly not between FS and NoNi.

Conclusion: This study suggests that current smokers suffer from alterations in both sleep architecture and ventilatory parameters, the later appears to persist even after smoking cessation.

Keywords: Obstructive sleep apnea syndrome; Polysomnography; Sleep architecture; Sleep parameters; Smoking; Tobacco.