Pseudomonas aeruginosa High-Risk Sequence Type 463 Co-Producing KPC-2 and AFM-1 Carbapenemases, China, 2020-2022

Piaopiao Zhang; Wenhao Wu; Nanfei Wang; Haiting Feng; Jie Wang; Fang Wang; Yan Zhang; Hongchao Chen; Qing Yang; Yan Jiang; Tingting Qu

doi:10.3201/eid2910.230509

Pseudomonas aeruginosa High-Risk Sequence Type 463 Co-Producing KPC-2 and AFM-1 Carbapenemases, China, 2020-2022

Emerg Infect Dis. 2023 Oct;29(10):2136-2140. doi: 10.3201/eid2910.230509.

Authors

Piaopiao Zhang, Wenhao Wu, Nanfei Wang, Haiting Feng, Jie Wang, Fang Wang, Yan Zhang, Hongchao Chen, Qing Yang, Yan Jiang, Tingting Qu

Abstract

We report the clonal spread and evolution of high-risk Pseudomonas aeruginosa sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases isolated from hospital patients in China during 2020-2022. Those strains pose a substantial public health threat and surveillance and stricter infection-control measures are essential to prevent further infections.

Keywords: AFM-1; China; KPC-2; Pseudomonas aeruginosa; ST463; antimicrobial resistance; bacteria; blaAFM-1; blaKPC-2; carbapenemase; clonal spread; respiratory infections; sequence type.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins* / genetics
China / epidemiology
Humans
Pseudomonas aeruginosa* / genetics
beta-Lactamases / genetics

Substances

carbapenemase
Bacterial Proteins
beta-Lactamases