Justice-involved youth experience high rates of mental health problems that require proper screening and assessment in order to effectively intervene. The Youth Self-Report (YSR) is a general psychopathology rating scale that measures several dimensions of psychopathology and is commonly used in clinical assessments, including with justice-involved youth. Yet, the underlying factor structure of the YSR has not been examined specifically in a sample of justice-involved youth. We examined the factor structure of the YSR using confirmatory factor analysis with a sample of 961 male youth involved with the justice system (12-18 years of age). Measurement invariance of the YSR was also examined across groups of youth who committed a sexual offence and those who committed a nonsexual offence. The eight-factor model presented with optimal fit to the data, consistent with previous research with nonjustice involved samples, and the model demonstrated strong measurement invariance across youth who committed both types of offenses (sexual and nonsexual). Youth who committed nonsexual offenses reported significantly higher degrees of rule-breaking behavior and lower degrees of social problems than youth who committed sexual offenses. The current findings provide strong psychometric evidence that supports the use of the YSR with justice-involved male youth. As such, clinicians and researchers can be confident in using the YSR as a mental health screening tool with male youth involved with the justice system who have committed various offenses. (PsycInfo Database Record (c) 2023 APA, all rights reserved).