Short review: novel concepts in the approach to patients with amiodarone-induced thyrotoxicosis

J Endocrinol Invest. 2024 Feb;47(2):275-283. doi: 10.1007/s40618-023-02168-3. Epub 2023 Sep 20.

Abstract

Introduction: Amiodarone-induced thyrotoxicosis is associated with high morbidity and mortality rates. The approach to this condition is widely variable across different medical specialists and even among expert endocrinologists. As a matter of fact, the approach to amiodarone-induced thyrotoxicosis has always been considered difficult, due to diagnostic uncertainties easily resulting in missteps, and therapeutic challenges easily resulting in unresponsiveness or slow-responsiveness to the administered drugs.

Purpose: Our purpose is to review novelties emerged during the last years about this condition, with the aim to provide novel insights on the diagnostic and therapeutic management of this challenging condition.

Keywords: Amiodarone; Cardiovascular; Hyperthyroidism; Thyroidectomy; Thyrotoxicosis.

Publication types

  • Review

MeSH terms

  • Amiodarone* / adverse effects
  • Anti-Arrhythmia Agents / adverse effects
  • Humans
  • Hyperthyroidism*
  • Thyroidectomy / methods
  • Thyrotoxicosis* / chemically induced
  • Thyrotoxicosis* / diagnosis

Substances

  • Amiodarone
  • Anti-Arrhythmia Agents