Focus on the performance enhancement of micro/nanomotor-based biosensors

Yi-Ran Song; Zi-Wei Song; Jia-Kang Wu; Zhe-Yi Li; Xiao-Feng Gu; Cong Wang; Lei Wang; Jun-Ge Liang

doi:10.1016/j.bios.2023.115686

Focus on the performance enhancement of micro/nanomotor-based biosensors

Biosens Bioelectron. 2023 Dec 1:241:115686. doi: 10.1016/j.bios.2023.115686. Epub 2023 Sep 9.

Authors

Yi-Ran Song¹, Zi-Wei Song², Jia-Kang Wu¹, Zhe-Yi Li³, Xiao-Feng Gu¹, Cong Wang⁴, Lei Wang⁵, Jun-Ge Liang⁶

Affiliations

¹ Engineering Research Center of IoT Technology Applications (Ministry of Education), Department of Electronic Engineering, Jiangnan University, Wuxi, 214122, China.
² Department of Microwave Engineering, Harbin Institute of Technology, Harbin, 150001, China.
³ Department of Microwave Engineering, Harbin Institute of Technology, Harbin, 150001, China; State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI), Qingdao, 266237, China.
⁴ Department of Microwave Engineering, Harbin Institute of Technology, Harbin, 150001, China. Electronic address: kevinwang@hit.edu.cn.
⁵ School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China; State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI), Qingdao, 266237, China. Electronic address: leiwang_chem@hit.edu.cn.
⁶ Engineering Research Center of IoT Technology Applications (Ministry of Education), Department of Electronic Engineering, Jiangnan University, Wuxi, 214122, China. Electronic address: jgliang@jiangnan.edu.cn.

PMID: 37729810
DOI: 10.1016/j.bios.2023.115686

Abstract

Micro/nanomotors (MNMs) emerge as a vital candidate for biosensing due to its nano-size structure, high surface-to-area ratio, directional mobility, biocompatibility, and ease of functionalization, therefore being able to detect objects with high efficiency, precision, and selectivity. The driving mode, nanostructure, materials property, preparation technique, and biosensing applications have been thoroughly discussed in publications. To promote the MNMs-based biosensors from in vitro to in vivo, it is necessary to give a comprehensive discussion from the perspective of sensing performances enhancement. However, until now, there is few reviews dedicated to the systematic discussion on the multiple performance enhancement schemes and the current challenges of MNMs-based biosensors. Bearing it in mind and based on our research experience in this field, we summarized the enhancement methods for biosensing properties such as sensitivity, selectivity, detection time, biocompatibility, simplify system operation, and environmental availability. We hope that this review provides the readers with fundamental understanding on performance enhancement schemes for MNMs-based biosensors.

Keywords: Biocompatibility; Biodetection; Biosensor; Micro/nanomotor; Selectivity; Sensitivity.

Publication types

Review