Changes in the global burden of foreign body aspiration among under-5 children from 1990 to 2019

Yuying Wu; Xin Zhang; Zaigang Lin; Chenyu Ding; Yuxuan Wu; Yue Chen; Desheng Wang; Xuehan Yi; Fa Chen

doi:10.3389/fped.2023.1235308

Changes in the global burden of foreign body aspiration among under-5 children from 1990 to 2019

Front Pediatr. 2023 Sep 1:11:1235308. doi: 10.3389/fped.2023.1235308. eCollection 2023.

Authors

Yuying Wu^#¹, Xin Zhang^#², Zaigang Lin³, Chenyu Ding⁴, Yuxuan Wu¹, Yue Chen⁴, Desheng Wang⁵, Xuehan Yi⁵, Fa Chen^{1

6}

Affiliations

¹ Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
² Fujian Branch of Shanghai Children's Medical Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Children's Hospital, Fujian Medical University, Fuzhou, China.
³ Laboratory Animal Center, Fujian Medical University, Fuzhou, China.
⁴ Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
⁵ Department of Otolaryngology Head and Neck Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
⁶ Clinical Research Unit, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.

^# Contributed equally.

Abstract

Background: To evaluate the changes in the global burden of foreign body aspiration (FBA) among children under 5 years old at regional, age, sex, and socio-demographic index (SDI) levels between 1990 and 2019.

Methods: Data on FBA was derived from the Global Burden of Disease (GBD) Study 2019 database on pulmonary aspiration and foreign body in airway. The means and 95% uncertainty intervals (UIs) were calculated for incidence, and disability-adjusted life-years (DALYs). The temporal trends were represented by estimated annual percentage change (EAPC) using Joinpoint regression.

Results: Globally, FBA caused 109.6 (95% UI: 69.5, 175.7) per 100,000 incidence and 317.9 (95% UI: 270.7, 372.4) per 100,000 DALYs under 5 years old in 2019. Many European countries (such as Italy, Netherlands, Iceland, etc.) showed a high incidence rate, but did not cause a large disease burden (DALYs all less than 200 per 100,000). Compared to 1990, although a decrease in both incidence and DALYs occurred in 2019, the Joinpoint regression showed an increasing trend in incidence rate from 2014 to 2019 [APC: both (2.10), female (2.25), male (1.98), P < 0.05)], especially China, Netherlands, and Malta. Despite the lower incidence rate in early neonatal group and middle SDI areas, they instead resulted in higher DALYs than other age groups and areas.

Conclusion: Although declines occurred in incidence and DALYs of FBA among children under 5 years of age from 1990 to 2014, an upward trend began to emerge from 2014 to 2019. The incidence and DALY rates were correlated with age and SDI. Increased efforts are needed to improve the necessary monitoring and reporting systems, hazard assessment, and public education activities.

Keywords: DALYs; foreign body aspiration; global burden; socio-demographic index; under-5 children.

Grants and funding

This work was supported by the High-level Talents research Start-up Project of Fujian Medical University (No. XRCZX2018001), and Program for Excellent Talents in the First Affiliated Hospital of Fujian Medical University (No. YYXQN-DCY2021).