B-type natriuretic peptide and N-terminal Pro-B-type natriuretic peptide in severe aortic stenosis: a comprehensive literature review

Pâmela Nogueira Cavalcante; Gabriel Kanhouche; Vitor Emer Egypto Rosa; Carlos M Campos; Mariana Pezzute Lopes; Maria Antonieta Albanez A de M Lopes; Roney Orismar Sampaio; Fábio Sândoli de Brito Júnior; Flavio Tarasoutchi; Alexandre Antonio Cunha Abizaid

doi:10.3389/fcvm.2023.1182530

B-type natriuretic peptide and N-terminal Pro-B-type natriuretic peptide in severe aortic stenosis: a comprehensive literature review

Front Cardiovasc Med. 2023 Sep 1:10:1182530. doi: 10.3389/fcvm.2023.1182530. eCollection 2023.

Affiliations

¹ Instituto do Coracao (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
² Departament of Hemodynamic, Instituto Prevent Senior, Sao Paulo, Brazil.

Abstract

B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are cardiac biomarkers that are released in response to increased ventricular and atrial wall stress. Aortic stenosis (AS) leads to hemodynamic changes and left ventricular hypertrophy and may be associated with natriuretic peptide levels. Several studies have shown that increased natriuretic peptide levels are correlated with AS severity and can predict the need for intervention. It can be useful in risk stratification, monitoring follow-up, and predicting cardiovascular outcomes of patients with severe AS. This paper aims to summarize the evidence of the role of BNP and NT-pro BNP in AS, before and after intervention.

Keywords: B-type natriuretic peptide; aortic stenosis; aortic valve replacement; biomarkers; natriuretic peptides.

Publication types

Review