ABO blood group-related mechanism of infection of SARS-CoV-2: an overview of systematic reviews

Massimo Franchini; Fabrizio Maggi; Daniele Focosi

doi:10.1515/cclm-2023-0825

ABO blood group-related mechanism of infection of SARS-CoV-2: an overview of systematic reviews

Clin Chem Lab Med. 2023 Sep 21;62(3):396-401. doi: 10.1515/cclm-2023-0825. Print 2024 Feb 26.

Authors

Massimo Franchini¹, Fabrizio Maggi², Daniele Focosi³

Affiliations

¹ Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy.
² Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy.
³ North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.

PMID: 37727133
DOI: 10.1515/cclm-2023-0825

Abstract

Among the host genetic factors playing a role in the susceptibility to infectious diseases, the ABO blood group system is of utmost importance. Following the first reports in early 2020, the association between ABO blood groups and SARS-CoV-2 infection or COVID-19 severity has been thoroughly investigated. The aim of this narrative review is to provide an overview of systematic reviews regarding the link between ABO blood groups and such risks. The possible molecular mechanisms underlying these associations will also be discussed. ABO blood group has a robust association with susceptibility to infection but not with disease severity, and studies on long COVID anre still missing.Prov.

Keywords: ABO blood group; COVID-19; SARS-CoV-2; infection.

Publication types

Review

MeSH terms

ABO Blood-Group System / genetics
COVID-19*
Humans
Post-Acute COVID-19 Syndrome
SARS-CoV-2*
Systematic Reviews as Topic

Substances

ABO Blood-Group System