mRNA vaccines in disease prevention and treatment

Gang Zhang; Tianyu Tang; Yinfeng Chen; Xing Huang; Tingbo Liang

doi:10.1038/s41392-023-01579-1

mRNA vaccines in disease prevention and treatment

Signal Transduct Target Ther. 2023 Sep 20;8(1):365. doi: 10.1038/s41392-023-01579-1.

Authors

Gang Zhang^#^{1

2

3

4

5}, Tianyu Tang^#^{1

2

3

4

5}, Yinfeng Chen^{1

2

3

4

5}, Xing Huang^{6

7

8

9

10}, Tingbo Liang^{11

12

13

14

15}

Affiliations

¹ Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China.
² Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, Zhejiang, China.
³ Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, 310003, Hangzhou, Zhejiang, China.
⁴ The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, 310009, Hangzhou, Zhejiang, China.
⁵ Cancer Center, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
⁶ Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China. huangxing66@zju.edu.cn.
⁷ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, Zhejiang, China. huangxing66@zju.edu.cn.
⁸ Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, 310003, Hangzhou, Zhejiang, China. huangxing66@zju.edu.cn.
⁹ The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, 310009, Hangzhou, Zhejiang, China. huangxing66@zju.edu.cn.
¹⁰ Cancer Center, Zhejiang University, 310058, Hangzhou, Zhejiang, China. huangxing66@zju.edu.cn.
¹¹ Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China. liangtingbo@zju.edu.cn.
¹² Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, Zhejiang, China. liangtingbo@zju.edu.cn.
¹³ Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, 310003, Hangzhou, Zhejiang, China. liangtingbo@zju.edu.cn.
¹⁴ The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, 310009, Hangzhou, Zhejiang, China. liangtingbo@zju.edu.cn.
¹⁵ Cancer Center, Zhejiang University, 310058, Hangzhou, Zhejiang, China. liangtingbo@zju.edu.cn.

^# Contributed equally.

Abstract

mRNA vaccines have emerged as highly effective strategies in the prophylaxis and treatment of diseases, thanks largely although not totally to their extraordinary performance in recent years against the worldwide plague COVID-19. The huge superiority of mRNA vaccines regarding their efficacy, safety, and large-scale manufacture encourages pharmaceutical industries and biotechnology companies to expand their application to a diverse array of diseases, despite the nonnegligible problems in design, fabrication, and mode of administration. This review delves into the technical underpinnings of mRNA vaccines, covering mRNA design, synthesis, delivery, and adjuvant technologies. Moreover, this review presents a systematic retrospective analysis in a logical and well-organized manner, shedding light on representative mRNA vaccines employed in various diseases. The scope extends across infectious diseases, cancers, immunological diseases, tissue damages, and rare diseases, showcasing the versatility and potential of mRNA vaccines in diverse therapeutic areas. Furthermore, this review engages in a prospective discussion regarding the current challenge and potential direction for the advancement and utilization of mRNA vaccines. Overall, this comprehensive review serves as a valuable resource for researchers, clinicians, and industry professionals, providing a comprehensive understanding of the technical aspects, historical context, and future prospects of mRNA vaccines in the fight against various diseases.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic
COVID-19* / prevention & control
Humans
Prospective Studies
Retrospective Studies
mRNA Vaccines

Substances

Adjuvants, Immunologic
mRNA Vaccines