Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Navneet Singh; Sukriti Vishwas; Amandeep Kaur; Harmanpreet Kaur; Violina Kakoty; Rubiya Khursheed; M V N L Chaitanya; Molakpogu Ravindra Babu; Ankit Awasthi; Leander Corrie; Vancha Harish; Palakurthi Yanadaiah; Saurabh Gupta; Amany A Sayed; Amr El-Sayed; Iftikhar Ali; Osama A Kensara; Nehmat Ghaboura; Gaurav Gupta; Ali M Dou; Mohammad Algahtani; Attalla F El-Kott; Kamal Dua; Sachin Kumar Singh; Mohamed M Abdel-Daim

doi:10.1016/j.biopha.2023.115512

Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Biomed Pharmacother. 2023 Nov:167:115512. doi: 10.1016/j.biopha.2023.115512. Epub 2023 Sep 17.

Authors

Navneet Singh¹, Sukriti Vishwas¹, Amandeep Kaur¹, Harmanpreet Kaur¹, Violina Kakoty¹, Rubiya Khursheed¹, M V N L Chaitanya¹, Molakpogu Ravindra Babu¹, Ankit Awasthi², Leander Corrie¹, Vancha Harish¹, Palakurthi Yanadaiah¹, Saurabh Gupta³, Amany A Sayed⁴, Amr El-Sayed⁵, Iftikhar Ali⁶, Osama A Kensara⁷, Nehmat Ghaboura⁸, Gaurav Gupta⁹, Ali M Dou¹⁰, Mohammad Algahtani¹¹, Attalla F El-Kott¹², Kamal Dua¹³, Sachin Kumar Singh¹⁴, Mohamed M Abdel-Daim¹⁵

Affiliations

¹ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
² School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; Department of pharmaceutics, ISF college of Pharmacy, Moga, Punjab 142001, India.
³ Chameli Devi Institute of Pharmacy, Department of pharmacology, Khandwa Road, Village Umrikheda, Near Toll booth, Indore, Madhya Pradesh 452020, India.
⁴ Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
⁵ Department of Animal Infectious Diseases, Faculty of Veterinary medicine, Cairo University, Egypt.
⁶ Department of Biochemistry and Cell Biology, State University of New York at Stonybrook, New York, USA.
⁷ Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 7067, Makkah 21955, Saudi Arabia.
⁸ Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, P. O. Box 6231, Jeddah 21442, Saudi Arabia.
⁹ Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India; School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, Jaipur, India.
¹⁰ Division of blood bank, Department of medical laboratories, Riyadh security forces hospital, Ministry of interior, Riyadh, Saudi Arabia.
¹¹ Department of Laboratory & Blood Bank, Security Forces Hospital, Mecca, Saudi Arabia.
¹² Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; Department of Zoology, College of Science, Damanhour University, Egypt.
¹³ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
¹⁴ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: singhsachin23@gmail.com.
¹⁵ Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address: abdeldaim.m@vet.suez.edu.eg.

PMID: 37725878
DOI: 10.1016/j.biopha.2023.115512

Abstract

Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.

Keywords: Bioavailability; Nanoformulations; Neurodegenerative diseases; Neuroprotective effects; Sesamol.

Publication types

Review