Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)

Mitsuki Umino; Mayumi Okuda; Takeshi Ohkubo; Tsutomu Fujii; Kiminori Matsubara

doi:10.1093/bbb/zbad135

Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)

Biosci Biotechnol Biochem. 2023 Nov 21;87(12):1537-1542. doi: 10.1093/bbb/zbad135.

Authors

Mitsuki Umino¹, Mayumi Okuda², Takeshi Ohkubo³, Tsutomu Fujii⁴, Kiminori Matsubara^{1

2}

Affiliations

¹ Department of Human Life Science Education, Graduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
² Department of Human Life Science Education, Graduate School of Education, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
³ Department of Health Nutrition, Sendai Shirayuri Women's College, Sehndai, Miyagi, Japan.
⁴ Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan.

PMID: 37723613
DOI: 10.1093/bbb/zbad135

Abstract

We evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.

Keywords: aging; glycerophosphocholine; hippocampus; microglia; neurogenesis.

MeSH terms

Animals
Blood-Brain Barrier*
Brain
Hippocampus
Inflammation
Mice
Microglia*
Neurogenesis

Abstract

MeSH terms

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