Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus

Chia-Hsiung Cheng; Chun-Che Hung; Yi-Ping Chao; Rui Nouchi; Pei-Ning Wang

doi:10.1016/j.clinph.2023.08.015

Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus

Clin Neurophysiol. 2023 Dec:156:281-289. doi: 10.1016/j.clinph.2023.08.015. Epub 2023 Sep 6.

Authors

Chia-Hsiung Cheng¹, Chun-Che Hung², Yi-Ping Chao³, Rui Nouchi⁴, Pei-Ning Wang⁵

Affiliations

¹ Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address: ch.cheng@mail.cgu.edu.tw.
² Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan.
³ Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
⁴ Department of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.
⁵ Division of General Neurology, Department of Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: pnwang@vghtpe.gov.tw.

PMID: 37722986
DOI: 10.1016/j.clinph.2023.08.015

Abstract

Objective: Subjective cognitive decline (SCD) is associated with increased risks for progressing to Alzheimer's disease (AD). This study aimed to investigate phase-amplitude coupling (PAC) in individuals with SCD and healthy controls (HCs) in the baseline year and determined the predictability of cognitive changes in the clinical follow-up.

Methods: Resting-state magnetoencephalographic signals in 29 HCs and 23 SCD subjects were recorded in the baseline year. The parahippocampal gyrus, posterior cingulate cortex and precuneus were selected as regions of interest (ROIs). Based on the grand-averaged comodulograms, delta-beta, delta-gamma and theta-gamma PAC values were extracted from each ROI.

Results: Compared with the HCs, the SCD group showed decreased theta-gamma PAC in the precuneus. Theta-gamma PAC of the left precuneus was associated with SCD severity and performance of immediate recall in the baseline year. The SCD group was followed for 3 years and divided into SCD-Stable and SCD-Decline groups based on scores of Mini-Mental State Examination. No significant differences in PAC of the baseline year were found between SCD-Stable and SCD-Decline groups.

Conclusions: The SCD group demonstrated reduced theta-gamma PAC in the precuneus.

Significance: Subjective perception of cognitive decline is reflected by objective alterations of brain function.

Keywords: Alzheimer’s disease; Cross-frequency coupling; Gamma; Magnetoencephalography (MEG); Subjective memory complaint; Theta.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease*
Cognitive Dysfunction* / diagnostic imaging
Humans
Magnetoencephalography
Memory, Short-Term / physiology
Parietal Lobe / diagnostic imaging