The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies

Jiuhui Xu; Qianyu Shi; Boyang Wang; Tao Ji; Wei Guo; Tingting Ren; Xiaodong Tang

doi:10.3389/fimmu.2023.1257254

The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies

Front Immunol. 2023 Sep 1:14:1257254. doi: 10.3389/fimmu.2023.1257254. eCollection 2023.

Authors

Jiuhui Xu^{1

2}, Qianyu Shi^{1

2}, Boyang Wang^{1

2}, Tao Ji^{1

2}, Wei Guo^{1

2}, Tingting Ren^{1

2}, Xiaodong Tang^{1

2}

Affiliations

¹ Department of Musculoskeletal Tumor, Peking University People's Hospital, Beijing, China.
² Beijing Key Laboratory of Musculoskeletal Tumor, Peking University People's Hospital, Beijing, China.

Abstract

Chordoma is a rare malignant bone tumor with limited therapeutic options, which is resistant to conventional chemotherapy and radiotherapy, and targeted therapy is also shown with little efficacy. The long-standing delay in researching its mechanisms of occurrence and development has resulted in the dilemma of no effective treatment targets and no available drugs in clinical practice. In recent years, the role of the tumor immune microenvironment in driving tumor growth has become a hot and challenging topic in the field of cancer research. Immunotherapy has shown promising results in the treatment of various tumors. However, the study of the immune microenvironment of chordoma is still in its infancy. In this review, we aim to present a comprehensive reveal of previous exploration on the chordoma immune microenvironment and propose promising immunotherapy strategies for chordoma based on these characteristics.

Keywords: chordoma; immune checkpoint inhibitor (ICI); immune-excluded; immunotherapy; tumor immune environment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chordoma* / therapy
Humans
Immunotherapy
Tumor Microenvironment

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (81972509) and the Beijing Natural Science Foundation (7232193).