Pulmonary manifestation of inflammatory bowel disease: Two case reports

Ayana Suzuki; Rintaro Noro; Jun Omori; Yasuhiro Terasaki; Toru Tanaka; Kazue Fujita; Natsuki Takano; Yumi Sakurai; Miyuri Suga; Anna Hayashi; Ken Okamura; Yoshinobu Saito; Kazuo Kasahara; Katsuhiko Iwakiri; Kaoru Kubota; Masahiro Seike

doi:10.1016/j.rmcr.2023.101914

Pulmonary manifestation of inflammatory bowel disease: Two case reports

Respir Med Case Rep. 2023 Aug 22:45:101914. doi: 10.1016/j.rmcr.2023.101914. eCollection 2023.

Authors

Affiliations

¹ Department of Respiratory Medicine, Nippon Medical School Hospital, Tokyo, Japan.
² Department of Gastroenterology and Hepatology, Nippon Medical School Hospital, Tokyo, Japan.
³ Department of Pathology, Nippon Medical School Hospital, Tokyo, Japan.

Abstract

Pulmonary involvement associated with inflammatory bowel disease (IBD) are a rare extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD), we herein presented two cases. Case 1: 53-year-old man with Crohn's disease treated with mesalazine and azathioprine. Pulmonary nodular shadows were incidentally detected on chest imaging, and revealed granulomas through transbronchial lung biopsy. Case 2: 68-year-old man with ulcerative colitis treated with mesalazine. He presented with fever and respiratory symptoms, and chest imaging showed multiple nodular infiltrates. He was diagnosed with organizing pneumonia by lung biopsy. Both cases were diagnosed to have pulmonary involvement associated with inflammatory bowel disease (IBD) according to multidisciplinary examination including positron emission tomography-computed tomography (FDG-PET) and pathological test. Pulmonary manifestations with IBD may not always require discontinuation of drugs or additional use of steroids or immunosuppressants.

Keywords: Crohn's disease; Inflammatory bowel disease; Pulmonary manifestation; Ulcerative colitis.

Publication types

Case Reports