The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways

Haydar M Al-Kuraishy; Majid S Jabir; Ali I Al-Gareeb; Ali K Albuhadily

doi:10.1016/j.arr.2023.102075

The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways

Ageing Res Rev. 2023 Nov:91:102075. doi: 10.1016/j.arr.2023.102075. Epub 2023 Sep 14.

Authors

Haydar M Al-Kuraishy¹, Majid S Jabir², Ali I Al-Gareeb¹, Ali K Albuhadily¹

Affiliations

¹ Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
² Department of Applied Science, University of Technology, Iraq. Electronic address: 100131@uotechnology.edu.iq.

PMID: 37714384
DOI: 10.1016/j.arr.2023.102075

Abstract

Parkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be increasing, reduced or unaffected. PRL level is dysregulated in different neurodegenerative disorders including PD. Preclinical and clinical studies pointed out that PRL may has a neuroprotective against PD neuropathology . Though, the mechanistic role of PRL in PD is not fully elucidated. Therefore, the objective of the present review was to clarify the potential role and mechanistic pathway of PRL in PD neuropathology. The present review highlighted that PRL appears to have a neuroprotective effect against PD neuropathology by inhibiting the expression of pro-inflammatory signaling pathways, antioxidant effects and by inhibiting neuroinflammation. Thus, preclinical and clinical studies are warranted in this regard.

Keywords: Ageing disorders; Cognitive dysfunction; Parkinson disease; Prolactin; Sleep disorders.

Publication types

Review

MeSH terms

Goals
Humans
Neurodegenerative Diseases*
Neuroprotective Agents* / pharmacology
Parkinson Disease* / drug therapy
Prolactin / metabolism
Prolactin / pharmacology

Substances

Prolactin
Neuroprotective Agents