Getting an aMPLe grasp on hematopoiesis

Samantha Joubran; Vijay G Sankaran

doi:10.1016/j.cell.2023.08.015

Getting an aMPLe grasp on hematopoiesis

Cell. 2023 Sep 14;186(19):4005-4006. doi: 10.1016/j.cell.2023.08.015.

Authors

Samantha Joubran¹, Vijay G Sankaran²

Affiliations

¹ Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA.
² Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: sankaran@broadinstitute.org.

PMID: 37714132
DOI: 10.1016/j.cell.2023.08.015

Abstract

Hematopoiesis requires balance between self-renewal of stem cells and differentiation into mature blood cells, orchestrated by pathways such as thrombopoietin signaling. In this issue of Cell, Tsutsumi et al. report the structure of the thrombopoietin ligand-receptor complex and demonstrate the potential to decouple its roles in self-renewal and hematopoietic differentiation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Differentiation
Cell Membrane
Hematopoiesis*
Signal Transduction
Thrombopoietin*

Substances

Thrombopoietin

Abstract

Publication types

MeSH terms

Substances

Grants and funding