Role of the tripartite motif (TRIM) family in female genital neoplasms

Tianyu Liu; Jian Chen; Jinjie Wu; Qiqiao Du; Junxiu Liu; Silu Tan; Yuwen Pan; Shuzhong Yao

doi:10.1016/j.prp.2023.154811

Role of the tripartite motif (TRIM) family in female genital neoplasms

Pathol Res Pract. 2023 Oct:250:154811. doi: 10.1016/j.prp.2023.154811. Epub 2023 Sep 9.

Authors

Tianyu Liu¹, Jian Chen², Jinjie Wu³, Qiqiao Du¹, Junxiu Liu¹, Silu Tan¹, Yuwen Pan¹, Shuzhong Yao⁴

Affiliations

¹ Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, China.
² Department of Thyroid and Hernia Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
³ Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
⁴ Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, China. Electronic address: yaoshuzh@mail.sysu.edu.cn.

PMID: 37713735
DOI: 10.1016/j.prp.2023.154811

Abstract

The tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital neoplasms, to provide a better understanding of its role in the development and progression of such diseases, and emphasize its potential as targeted cancer therapy. Overall, our review highlighted that the wide-ranging roles of TRIMs, in not only target protein ubiquitination, tumor migration and/or invasion, epithelial-mesenchymal transition, stemness, cell adhesion, proliferation, cell cycle regulation, and apoptosis, but also in influencing estrogenic, and chemotherapy response.

Keywords: Chemotherapy; TRIMs, female genital neoplasms; Ubiquitin E3 ligases.

Publication types

Review