Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity

Sephora Mutombo Mianda; Phanankosi Moyo; Suzan Maboane; Lyn-Marié Birkholtz; Vinesh J Maharaj

doi:10.1080/14786419.2023.2255921

Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity

Nat Prod Res. 2023 Sep 15:1-13. doi: 10.1080/14786419.2023.2255921. Online ahead of print.

Authors

Sephora Mutombo Mianda¹, Phanankosi Moyo^{1

2}, Suzan Maboane², Lyn-Marié Birkholtz², Vinesh J Maharaj¹

Affiliations

¹ Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.
² Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, South Africa.

PMID: 37712398
DOI: 10.1080/14786419.2023.2255921

Abstract

Three new steroids, turranin M, N and O (1-3), together with four known limonoids, nymania 1 (4), rubralin B (5), aphapolynin C (6) and Trichillia substance Tr B (7), were isolated from the leaves of Turraea obtusifolia. Their chemical structures were elucidated using NMR and MS. Rubralin B (5) displayed good activity against the asexual parasites from the drug sensitive Plasmodium falciparum NF54 strain with an IC₅₀ value of 3.47 µg/mL (4.57 µM), nymania 1 (4) showed a weak activity (IC₅₀ 13.36 µg/mL (19.40 µM)) and the rest of compounds had IC₅₀ > 20 µg/mL.

Keywords: Turraea obtusifolia; limonoids; plasmodium falciparum; steroids.