Levels of angiopoietin-2 are predictive for mortality in yellow fever virus infected patients

Cornelia A M van de Weg; Mateus V Thomazella; Mariana P Marmorato; Carolina A Correia; Juliana Z C Dias; Alvino Maestri; Luiz G F A B E Zanella; Natalia B Cerqueira; Alvina C Félix; Carlos H V Moreira; Renata Buccheri; Priscilla R Costa; Esper G Kallás

doi:10.1093/infdis/jiad389

Levels of angiopoietin-2 are predictive for mortality in yellow fever virus infected patients

J Infect Dis. 2023 Sep 15:jiad389. doi: 10.1093/infdis/jiad389. Online ahead of print.

Authors

Cornelia A M van de Weg^{1

2}, Mateus V Thomazella¹, Mariana P Marmorato¹, Carolina A Correia¹, Juliana Z C Dias¹, Alvino Maestri¹, Luiz G F A B E Zanella¹, Natalia B Cerqueira³, Alvina C Félix⁴, Carlos H V Moreira^{5

6

7}, Renata Buccheri⁵, Priscilla R Costa¹, Esper G Kallás^{1

6}

Affiliations

¹ Medical Investigation Laboratory 60 (LIM-60), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
² Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
³ Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
⁴ Institute of Tropical Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.
⁵ Infectious Diseases Institute "Emílio Ribas", São Paulo, SP, Brazil.
⁶ Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
⁷ Division of HIV, ID, & Global Medicine, University of California, San Francisco, Zuckerberg San Francisco General Hospital, USA.

PMID: 37711029
DOI: 10.1093/infdis/jiad389

Abstract

In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, haemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in the disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin-2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe patients and provide care to improve disease outcome.

Keywords: Angiopoietin-2; Endothelial damage; Yellow fever.