Progress in quantum dot-based biosensors for microRNA assay: A review

Wen-Jing Liu; Li-Juan Wang; Chun-Yang Zhang

doi:10.1016/j.aca.2023.341615

Progress in quantum dot-based biosensors for microRNA assay: A review

Anal Chim Acta. 2023 Oct 16:1278:341615. doi: 10.1016/j.aca.2023.341615. Epub 2023 Jul 13.

Authors

Wen-Jing Liu¹, Li-Juan Wang², Chun-Yang Zhang³

Affiliations

¹ School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
² School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. Electronic address: wanglijuan@seu.edu.cn.
³ School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. Electronic address: zhangcy@seu.edu.cn.

PMID: 37709484
DOI: 10.1016/j.aca.2023.341615

Abstract

MicroRNAs (miRNAs) are responsible for post-transcriptional gene regulation, and may function as valuable biomarkers for diseases diagnosis. Accurate and sensitive analysis of miRNAs is in great demand. Quantum dots (QDs) are semiconductor nanomaterials with superior optoelectronic features, such as high quantum yield and brightness, broad absorption and narrow emission, long fluorescence lifetime, and good photostability. Herein, we give a comprehensive review about QD-based biosensors for miRNA assay. Different QD-based biosensors for miRNA assay are classified by the signal types including fluorescent, electrochemical, electrochemiluminescent, and photoelectrochemical outputs. We highlight the features, principles, and performances of the emerging miRNA biosensors, and emphasize the challenges and perspectives in this field.

Keywords: Biosensors; Electrochemical; Electrochemiluminescent; Fluorescent; Photoelectrochemical; Quantum dots; microRNAs.

Publication types

Review

MeSH terms

Biological Assay
Coloring Agents
MicroRNAs*
Quantum Dots*
Semiconductors

Substances

Coloring Agents
MicroRNAs