Over but not gone: lingering epigenetic effects of COVID-19

Brandon T Tran; Ruoqiong Cao; Katherine Y King

doi:10.1016/j.it.2023.08.012

Over but not gone: lingering epigenetic effects of COVID-19

Trends Immunol. 2023 Oct;44(10):751-753. doi: 10.1016/j.it.2023.08.012. Epub 2023 Sep 11.

Authors

Brandon T Tran¹, Ruoqiong Cao², Katherine Y King³

Affiliations

¹ Program in Cancer and Cell Biology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.
² Program in Immunology and Microbiology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.
³ Program in Cancer and Cell Biology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA; Program in Immunology and Microbiology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA; Department of Pediatrics, Division of Infectious Disease, Baylor College of Medicine, Houston, TX, USA. Electronic address: Kyk@bcm.edu.

PMID: 37704548
PMCID: PMC10543559 (available on 2024-10-01)
DOI: 10.1016/j.it.2023.08.012

Abstract

'Long COVID' affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
COVID-19* / genetics
Epigenesis, Genetic
Humans
Post-Acute COVID-19 Syndrome
SARS-CoV-2

Abstract

Publication types

MeSH terms

Grants and funding