Using light to drive energy transduction in metazoan aging

Vaibhav Tiwary; Anne-Marie Galow; Andrew P Wojtovich; Shahaf Peleg

doi:10.1016/j.tibs.2023.08.010

Using light to drive energy transduction in metazoan aging

Trends Biochem Sci. 2023 Nov;48(11):920-922. doi: 10.1016/j.tibs.2023.08.010. Epub 2023 Sep 11.

Authors

Vaibhav Tiwary¹, Anne-Marie Galow², Andrew P Wojtovich³, Shahaf Peleg⁴

Affiliations

¹ Research Group Epigenetics, Metabolism, and Longevity, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.
² Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.
³ University of Rochester Medical Center, Department of Anesthesiology and Perioperative Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: andrew_wojtovich@urmc.rochester.edu.
⁴ Research Group Epigenetics, Metabolism, and Longevity, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. Electronic address: peleg@fbn-dummerstorf.de.

PMID: 37704489
PMCID: PMC10592090 (available on 2024-11-01)
DOI: 10.1016/j.tibs.2023.08.010

Abstract

Mitochondrial dysfunction is a central hallmark of aging and energy transduction is a promising target for longevity interventions. New research suggests that interventions in how energy is transduced could benefit healthy longevity. Here, we propose using light as an alternative energy source to fuel mitochondria and increase metazoan lifespan.

Keywords: bioenergetics; lifespan; metabolism; mitochondria; optogenetics; proton pump.

Abstract

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