KNOTTED1-like homeobox (KNOX) transcription factors - Hubs in a plethora of networks: A review

Int J Biol Macromol. 2023 Dec 31;253(Pt 3):126878. doi: 10.1016/j.ijbiomac.2023.126878. Epub 2023 Sep 12.

Abstract

KNOX (KNOTTED1-like HOMEOBOX) belongs to a class of important homeobox genes, which encode the homeodomain proteins binding to the specific element of target genes, and widely participate in plant development. Advancements in genetics and molecular biology research generate a large amount of information about KNOX genes in model and non-model plants, and their functions in different developmental backgrounds are gradually becoming clear. In this review, we summarize the known and presumed functions of the KNOX gene in plants, focusing on horticultural plants and crops. The classification and structural characteristics, expression characteristics and regulation, interacting protein factors, functions, and mechanisms of KNOX genes are systematically described. Further, the current research gaps and perspectives were discussed. These comprehensive data can provide a reference for the directional improvement of agronomic traits through KNOX gene regulation.

Keywords: Horticulture; KNOX transcription factors; Protein interaction.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation, Plant
  • Genes, Homeobox* / genetics
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Phenotype
  • Plant Proteins / metabolism
  • Plants / genetics
  • Plants / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Transcription Factors
  • Homeodomain Proteins
  • Plant Proteins