A universe of second messengers for cGLR-STING signaling

Xubiao Wei; Conggang Zhang

doi:10.1016/j.immuni.2023.08.017

A universe of second messengers for cGLR-STING signaling

Immunity. 2023 Sep 12;56(9):1975-1977. doi: 10.1016/j.immuni.2023.08.017.

Authors

Xubiao Wei¹, Conggang Zhang²

Affiliations

¹ State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
² State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. Electronic address: cgzhang@tsinghua.edu.cn.

PMID: 37703824
DOI: 10.1016/j.immuni.2023.08.017

Abstract

2'3'-cyclic GMP-AMP (2'3'-cGAMP) and 3'2'-cGAMP activate STING-dependent antiviral immunity in Drosophila melanogaster but fail to control infection by C virus in some fly species. In this issue of Immunity, Cai et al. reveal that Drosophila produces multiple cyclic di-nucleotides (CDNs) in response to viral infection. One of these CDNs-2'3'-c-di-GMP-is a very potent STING activator capable of promoting antiviral immunity in otherwise susceptible flies.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antiviral Agents
Drosophila
Drosophila melanogaster*
Second Messenger Systems*
Signal Transduction

Substances

Antiviral Agents