A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022

Changkai Hou; Wen Ren; Bangyue Wang; Xi'an Fu; Quanlei Liu; Jian Li; Hao Zhang; Weihan Wang; Xinyu Yang; Penghu Wei; Guoguang Zhao

doi:10.3389/fnmol.2023.1148179

A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022

Front Mol Neurosci. 2023 Aug 28:16:1148179. doi: 10.3389/fnmol.2023.1148179. eCollection 2023.

Authors

Changkai Hou¹, Wen Ren², Bangyue Wang³, Xi'an Fu⁴, Quanlei Liu¹, Jian Li³, Hao Zhang⁵, Weihan Wang⁶, Xinyu Yang³, Penghu Wei¹, Guoguang Zhao¹

Affiliations

¹ Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China.
² Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
³ Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
⁴ Department of Neurosurgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
⁵ Department of Neurosurgery, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China.
⁶ Department of Neurosurgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Abstract

Objective: To explore the development context, research hotspots and frontiers in the glymphatic system (GS) field from 2012 to 2022 by bibliometric analysis.

Methods: The Web of Science Core Collection (WoSCC) database was searched for articles published between 2012 and 2022. Microsoft Excel was used to manage the data. VOSviewer, CiteSpace, GraphPad Prism, the Web of Science, and an online analysis platform for bibliometrics (http://bibliometric.com/) were used to analyze the countries, institutions, journals, and collaboration networks among authors and the types of articles, developmental directions, references, and top keywords of published articles.

Results: A total of 412 articles were retrieved, including 39 countries/regions, 223 research institutes and 171 academic journals. The subject classifications related to the GS were Neuroscience, Clinical Neuroscience and Radiology/Nuclear Medicine/Medical Imaging. The United States has maintained its dominant and most influential position in GS research. Among research institutions and journals, the Univ Rochester and Journal of Cerebral Blood Flow and Metabolism had the highest number of academic articles, respectively. Nedergaard M had the most published article, and Iliff JJ had the most co-citations. The top two keywords with the highest frequency were "glymphatic system" and "cerebrospinal fluid."

Conclusion: This research provides valuable information for the study of the GS. The bibliometric analysis of this area will encourage potential collaborations among researchers, defining its frontiers and directions for development.

Keywords: CiteSpace; VOSviewer; WoSCC; bibliometrics; glymphatic system; visualization.