The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report

Weiling Zhou; Qian Gao; Lianjing Wang; Weijing Li; Cuiying He; Yanting Li; Lei Feng; Wei Liu; Lihong Liu; Yuan Wang

doi:10.2147/CMAR.S427217

The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report

Cancer Manag Res. 2023 Sep 6:15:983-988. doi: 10.2147/CMAR.S427217. eCollection 2023.

Authors

Weiling Zhou¹, Qian Gao¹, Lianjing Wang², Weijing Li², Cuiying He², Yanting Li³, Lei Feng¹, Wei Liu², Lihong Liu², Yuan Wang¹

Affiliations

¹ Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang, HeBei Province, 050000, People's Republic of China.
² Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, HeBei Province, 050000, People's Republic of China.
³ Department of Glandular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, HeBei Province, 050000, People's Republic of China.

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) involving the breast, spleen, and bone in a male patient with hepatitis B virus (HBV) infection is extremely rare in clinical practice.

Case presentation: We report a case of DLBCL involving the breast, spleen, and bone (triple expression of Bcl-2⁺, Bcl-6⁺, and 70% positive C-mcy) in a male patient with HBV admitted to our hospital. The patient was treated with EPOCH×4, lenalidomide+EPOCH×2 chemotherapy, intermittent methotrexate intrathecal injections to prevent central invasion, and autologous stem cell transplantation (ASCT). The patient is currently in complete remission, and the follow-up time was 43 months.

Conclusion: A patient with DLBCL involving the breast, spleen, and bone can be treated with a combination of multiple regimens. If the patient's economic conditions permit it, ASCT can be considered.

Keywords: autologous stem cell transplantation; breast; diffuse large B-cell lymphoma; triple expression; viral hepatitis B.

Publication types

Case Reports

Grants and funding

This research was supported by the Department of Science and Technology of Hebei Province of China (No. 20221232, No. 20230803 and No. 20221266).