HLA-DRB1 and HLA-DQA1 associated with immunogenicity to adalimumab therapy in patients with rheumatoid arthritis

Ann Rheum Dis. 2024 Jan 11;83(2):263-265. doi: 10.1136/ard-2023-223955.

Chuan Fu Yap¹, Nisha Nair^{1

2}, Annick de Vries³, Floris C Loeff³, Ann W Morgan^{4

5

6}, John D Isaacs^{7

8}, Anthony G Wilson⁹, Kimme L Hyrich^{2

10}, Anne Barton^{1

2}, Darren Plant¹¹

¹ Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
² NIHR Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
³ Diagnostic Services, Sanquin, Amsterdam, The Netherlands.
⁴ School of Medicine, University of Leeds, Leeds, UK.
⁵ NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁶ NIHR In Vitro Diagnostic Co-operative, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁷ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
⁸ Musculoskeletal Unit, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK.
⁹ School of Medicine and Medical Science, Conway Institute, University College Dublin, University College Dublin, Dublin, Ireland.
¹⁰ Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
¹¹ Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK Darren.Plant@manchester.ac.uk.

No abstract available

Keywords: Adalimumab; Arthritis, Rheumatoid; Autoantibodies; Methotrexate.

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