Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Zsolt Megyesfalvi; Simon Heeke; Benjamin J Drapkin; Anna Solta; Ildiko Kovacs; Kristiina Boettiger; Lilla Horvath; Busra Ernhofer; Janos Fillinger; Ferenc Renyi-Vamos; Clemens Aigner; Karin Schelch; Christian Lang; Gyorgy Marko-Varga; Carl M Gay; Lauren A Byers; Benjamin B Morris; John V Heymach; Peter Van Loo; Fred R Hirsch; Balazs Dome

doi:10.1016/j.ccell.2023.08.007

Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Cancer Cell. 2023 Sep 11;41(9):1535-1540. doi: 10.1016/j.ccell.2023.08.007.

Authors

Zsolt Megyesfalvi¹, Simon Heeke², Benjamin J Drapkin³, Anna Solta⁴, Ildiko Kovacs⁵, Kristiina Boettiger⁴, Lilla Horvath⁵, Busra Ernhofer⁴, Janos Fillinger⁵, Ferenc Renyi-Vamos⁶, Clemens Aigner⁴, Karin Schelch⁷, Christian Lang⁸, Gyorgy Marko-Varga⁹, Carl M Gay², Lauren A Byers², Benjamin B Morris², John V Heymach², Peter Van Loo¹⁰, Fred R Hirsch¹¹, Balazs Dome¹²

Affiliations

¹ Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary; National Koranyi Institute of Pulmonology, Budapest, Hungary.
² Department of Thoracic / Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁴ Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
⁵ National Koranyi Institute of Pulmonology, Budapest, Hungary.
⁶ Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary; National Koranyi Institute of Pulmonology, Budapest, Hungary.
⁷ Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Center for Cancer Research, Medical University of Vienna, Vienna, Austria.
⁸ Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Division of Pulmonology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
⁹ Department of Biomedical Engineering, Lund University, Lund, Sweden.
¹⁰ Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹¹ Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Tisch Cancer Institute, Center for Thoracic Oncology, Mount Sinai Health System, New York, NY, USA. Electronic address: fred.hirsch@mssm.edu.
¹² Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary; National Koranyi Institute of Pulmonology, Budapest, Hungary; Department of Translational Medicine, Lund University, Lund, Sweden. Electronic address: balazs.dome@meduniwien.ac.at.

PMID: 37699331
DOI: 10.1016/j.ccell.2023.08.007

Abstract

The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

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