Research progress on the pathogenesis of diabetic retinopathy

Abstract

Diabetic retinopathy is one of the most common and serious microvascular complications of diabetes mellitus. There are many factors leading to diabetic retinopathy, and its pathogenesis is still unclear. At present, there are still no effective measures for the early treatment of diabetic retinopathy, and the treatment options available when diabetes progresses to advanced stages are very limited, and the treatment results are often unsatisfactory. Detailed studies on the molecular mechanisms of diabetic retinopathy pathogenesis and the development of new therapeutic agents are of great importance. This review describes the potential pathogenesis of diabetic retinopathy for experimental studies and clinical practice.

Keywords: Amino acid metabolism; Diabetic retinopathy; Gene epigenetic inheritance; Hemoglobin; Inflammatory reaction; Intestinal flora; Mitochondrial disorders; Oxidative stress.