Role of the placenta in developmental programming: Observations from models using large animals

L P Reynolds; C R Dahlen; A K Ward; M S Crouse; P P Borowicz; B J Davila-Ruiz; C Kanjanaruch; K A Bochantin; K J McLean; K L McCarthy; A C B Menezes; W J S Diniz; R A Cushman; J S Caton

doi:10.1016/j.anireprosci.2023.107322

Role of the placenta in developmental programming: Observations from models using large animals

Anim Reprod Sci. 2023 Oct:257:107322. doi: 10.1016/j.anireprosci.2023.107322. Epub 2023 Aug 30.

Authors

L P Reynolds¹, C R Dahlen², A K Ward², M S Crouse³, P P Borowicz², B J Davila-Ruiz², C Kanjanaruch², K A Bochantin², K J McLean⁴, K L McCarthy⁵, A C B Menezes⁶, W J S Diniz⁷, R A Cushman³, J S Caton²

Affiliations

¹ Center for Nutrition and Pregnancy, and Department of Animal Sciences, North Dakota State University, Fargo, ND 58108-6050, USA. Electronic address: larry.reynolds@ndsu.edu.
² Center for Nutrition and Pregnancy, and Department of Animal Sciences, North Dakota State University, Fargo, ND 58108-6050, USA.
³ Nutrition, Growth, and Physiology Research Unit, USDA/Agricultural Research Service, U.S. Meat Animal Research Center, Clay Center, NE 68933-0166, USA.
⁴ Department of Animal Science, University of Tennessee Knoxville, Knoxville, TN 37996-4500, USA.
⁵ Department of Animal Science, University of Nebraska Lincoln, Lincoln, NE 68583-0908, USA.
⁶ Department of Animal Science, South Dakota State University, Brookings, SD 57006, USA.
⁷ Department of Animal Sciences, Auburn University, Auburn, AL 36832, USA.

PMID: 37696224
PMCID: PMC10591737 (available on 2024-10-01)
DOI: 10.1016/j.anireprosci.2023.107322

Abstract

Developmental programming, which proposes that "insults" or "stressors" during intrauterine or postnatal development can have not only immediate but also long-term consequences for healthy and productivity, has emerged as a major biological principle, and based on studies in many animal species also seems to be a universal phenomenon. In eutherians, the placenta appears to be programmed during its development, which has consequences for fetal growth and development throughout pregnancy, and likewise has long-term consequences for postnatal development, leading to programming of organ function of the offspring even into adulthood. This review summarizes our current understanding of the placenta's role in developmental programming, the mechanisms involved, and the challenges remaining.

Keywords: Blood flow; Developmental programming; Fetal growth; Function; Placenta; Vascularity.

Publication types

Review

MeSH terms

Animals
Female
Fetal Development*
Placenta*
Pregnancy

Abstract

Publication types

MeSH terms

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