Investigation on hydrodynamic lubrication effect of micro groove seal in pharmaceutical kettle

PLoS One. 2023 Sep 11;18(9):e0291360. doi: 10.1371/journal.pone.0291360. eCollection 2023.

Abstract

To improve the lubrication conditions of the seal in the pharmaceutical kettles, a specific shape groove with micrometer level on the sealing end face is set up to fully utilize the fluid dynamic pressure effect under given working conditions. A numerical model is developed to solve the pressure distribution in the micro groove, where any groove shape can be used. The numerical form of the model is derived using the principle of mass conservation without considering the film thickness derivative term, and the coordinate transformation is introduced to adapt to the curved shape of the groove. The cavitation phenomenon is taken into account in the flow field of the seal, and the JFO cavitation model is introduced to modify the Reynolds equation. The diversity of groove shapes is considered, and the node adsorption method is adopted to approximate the groove shape. The model is established based on the principle of mass conservation, which can adapt to any different groove shapes and has a strong scalability. By mathematical modeling and solving, the performances of the micro groove seal under different groove shapes are analyzed, providing a basis for the micro groove design of seal in pharmaceutical kettles.

MeSH terms

  • Animals
  • Caniformia*
  • Hydrodynamics
  • Lubrication
  • Pharmaceutical Preparations
  • Seals, Earless*

Substances

  • Pharmaceutical Preparations

Grants and funding

The author(s) received no specific funding for this work.