Long-term stable wireless smart contact lens for robust digital diabetes diagnosis

Hye Hyeon Han; Su-Kyung Kim; Seong-Jong Kim; Inhoo Choi; Jee Won Mok; Choun-Ki Joo; Sangbaie Shin; Sei Kwang Hahn

doi:10.1016/j.biomaterials.2023.122315

Long-term stable wireless smart contact lens for robust digital diabetes diagnosis

Biomaterials. 2023 Nov:302:122315. doi: 10.1016/j.biomaterials.2023.122315. Epub 2023 Sep 4.

Authors

Hye Hyeon Han¹, Su-Kyung Kim², Seong-Jong Kim², Inhoo Choi², Jee Won Mok³, Choun-Ki Joo³, Sangbaie Shin⁴, Sei Kwang Hahn⁵

Affiliations

¹ Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, South Korea. Electronic address: hhhappy@postech.ac.kr.
² Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, South Korea.
³ Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 06591, South Korea.
⁴ PHI BIOMED Co., #613, 12 Gangnam-daero 65-gil, Seocho-gu, Seoul, 06612, South Korea.
⁵ Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, South Korea; PHI BIOMED Co., #613, 12 Gangnam-daero 65-gil, Seocho-gu, Seoul, 06612, South Korea. Electronic address: skhanb@postech.ac.kr.

PMID: 37689048
DOI: 10.1016/j.biomaterials.2023.122315

Abstract

Wearable devices for digital continuous glucose monitoring (CGM) have attracted great attention as a new paradigm medical device for diabetes management. However, the relatively inaccurate performance and instability of CGM devices have limited their wide applications in the clinic. Here, we developed hyaluronate (HA) modified Au@Pt bimetallic electrodes for long-term accurate and robust CGM of smart contact lens. After glucose oxidation reaction, the bimetallic electrodes facilitated the rapid decomposition of hydrogen peroxide and charge transfer for robust CGM. The passivation of Au@Pt bimetallic electrode with branch-type thiolated HA prevented the dissolution of Au electrode by chloride ions in tears. In diabetic and normal rabbits, the smart contact lens with HA-Au@Pt bimetallic electrodes enabled the high correlation (ρ = 0.88) CGM with 98.6% clinically acceptable data for 3 weeks. Taken together, we could confirm the feasibility of our smart contact lens for long-term CGM for further clinical development.

Keywords: Bimetallic electrode; Diabetes diagnosis; Glucose sensor; Hyaluronate; Smart contact lens.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose
Blood Glucose Self-Monitoring
Contact Lenses*
Diabetes Mellitus*
Glucose
Glycosaminoglycans
Rabbits

Substances

Blood Glucose
Glucose
Glycosaminoglycans