Increased IL-10-competent regulatory B cells in the decidua of early human pregnancy

Shigeki Shimada; Hiroki Sakamoto; Norifumi Iijima; Atsushi Fukui; Yutoku Shi; Masashi Deguchi; Hideto Yamada

doi:10.1016/j.jri.2023.104142

Increased IL-10-competent regulatory B cells in the decidua of early human pregnancy

J Reprod Immunol. 2023 Dec:160:104142. doi: 10.1016/j.jri.2023.104142. Epub 2023 Sep 4.

Authors

Shigeki Shimada¹, Hiroki Sakamoto², Norifumi Iijima³, Atsushi Fukui⁴, Yutoku Shi⁵, Masashi Deguchi⁵, Hideto Yamada⁶

Affiliations

¹ Mommy's Clinic Chitose, Chitose, Japan.
² Department of cellular immunology, Sapporo Clinical Laboratory Inc., Sapporo, Japan.
³ National Institutes of Biomedical Innovation, Health and Nutrition, Laboratory of Nuclear Transport Dynamics, Osaka, Japan.
⁴ Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.
⁵ Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
⁶ Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan; Center for Recurrent Pregnancy Loss, Teine Keijinkai Hospital, Sapporo, Japan. Electronic address: yamada-hideto@keijinkai.or.jp.

PMID: 37683533
DOI: 10.1016/j.jri.2023.104142

Abstract

Regulatory B cells (Bregs) may play a pivotal role in maintaining human pregnancy. For the first time, to the best of our knowledge, this study noted that cell percentages of CD24^hiCD38^hi Bregs and CD24^hiCD27⁺ Bregs, which can potentially produce IL-10, are increased in human decidua compared with the mid-luteal phase endometrium. In each case of decidua, the correlation between Bregs and dendritic cell (DC) or natural killer (NK) cell expression was further explored. A positive correlation between the percentage of CD24^hiCD38^hi Bregs and CD123^-CD11c⁺ myeloid DCs (mDCs) was noted. Furthermore, a significant positive correlation was also observed between the percentage of CD24^hiCD27⁺ Bregs and CD94⁺CD56^brightCD16^- suppressive NK cells. These findings regarding decidual Bregs deepen the understanding of the harmonious immunological microenvironment that sustains early human pregnancy.

Keywords: Decidua; Dendritic cells; Early human pregnancy; Natural killer cells; Regulatory B cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

B-Lymphocytes, Regulatory*
Decidua
Female
Humans
Interleukin-10 / metabolism
Pregnancy

Substances

Interleukin-10