Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity

Hui Zhang; Chunhua Liu; Xiaoqian Zhai; Qianqian Zhang; Yao Zhou; Hu Huang; Mingde Ding; Qiang Shi; Yan Liu; Ying Tang; Guanghai Liu; Hongmei Wang

doi:10.1016/j.intimp.2023.110907

Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity

Int Immunopharmacol. 2023 Nov;124(Pt A):110907. doi: 10.1016/j.intimp.2023.110907. Epub 2023 Sep 7.

Authors

Hui Zhang¹, Chunhua Liu², Xiaoqian Zhai³, Qianqian Zhang⁴, Yao Zhou¹, Hu Huang³, Mingde Ding¹, Qiang Shi⁵, Yan Liu⁶, Ying Tang⁷, Guanghai Liu⁸, Hongmei Wang⁹

Affiliations

¹ Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China.
² Department of Physiology and Neurobiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250012, China.
³ Department of Pathology, the Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China.
⁴ Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250012, China.
⁵ Department of Radiology, the Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China.
⁶ Department of Ultrasound, the Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China.
⁷ Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, No.87, Dingjiaqiao, Gulou District, Nanjing, 210009, China.
⁸ Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China. Electronic address: lgh2003004@163.com.
⁹ School of Medicine, Southeast University, No.87, Dingjiaqiao, Gulou District, Nanjing, 210009, China. Electronic address: 101012573@seu.edu.cn.

PMID: 37683397
DOI: 10.1016/j.intimp.2023.110907

Abstract

Minimal deviation adenocarcinoma (MDA) of the uterine cervix, also referred to as malignant adenoma, is a rare subtype of cervical adenocarcinoma that exhibits histological characteristics resembling those of benign tumors, resulting in a low diagnostic rate and a lack of effective treatment options. The transcriptomic features of MDA at the single-cell resolution and within the tumor microenvironment (TME) remain unclear. In this study, we conducted single-cell transcriptomic analyses of MDA samples (Ca) and adjacent normal tissues (PCa). The present study reveals the prevalence of dendritic cells (DCs) and T cells in the carcinoma (Ca) of mammary ductal adenocarcinoma (MDA), with DCs undergoing significant metabolic reprogramming and immune stress. Additionally, our findings demonstrate the crucial involvement of DCs and T cells in the pathogenesis and metastatic progression of MDA, as evidenced by single-cell transcriptomic profiling of MDA and HPV samples. This resource provides a more profound understanding of the indolent nature of MDA and may prove useful in the development of MDA immunotherapy.

Keywords: Adenocarcinoma; Dendritic cells; Malignant adenoma; T cells; Uterine cervix.