Dynamics of the Streptomyces chromosome: chance and necessity

Stéphanie Bury-Moné; Annabelle Thibessard; Virginia S Lioy; Pierre Leblond

doi:10.1016/j.tig.2023.07.008

Dynamics of the Streptomyces chromosome: chance and necessity

Trends Genet. 2023 Nov;39(11):873-887. doi: 10.1016/j.tig.2023.07.008. Epub 2023 Sep 6.

Authors

Stéphanie Bury-Moné¹, Annabelle Thibessard², Virginia S Lioy³, Pierre Leblond²

Affiliations

¹ Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Electronic address: stephanie.bury-mone@i2bc.paris-saclay.fr.
² Université de Lorraine, INRAE, DynAMic, F-54000 Nancy, France.
³ Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.

PMID: 37679290
DOI: 10.1016/j.tig.2023.07.008

Abstract

Streptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. Remarkably, these bacteria possess a large linear chromosome that is genetically compartmentalized: core genes are grouped in the central part, while the ends are populated by poorly conserved genes including antibiotic biosynthetic gene clusters. The genome is highly unstable and exhibits distinct evolutionary rates along the chromosome. Recent chromosome conformation capture (3C) and comparative genomics studies have shed new light on the interplay between genome dynamics in space and time. Here, we review insights that illustrate how the balance between chance (random genome variations) and necessity (structural and functional constraints) may have led to the emergence of spatial structuring of the Streptomyces chromosome.

Keywords: 3D conformation; adaptation; core genome; genetic compartmentalization; genome evolution; spatial compartments.

Publication types

Review