A Novel Daratumumab-Based Regimen for Desensitization in Highly HLA-Presensitized Patients Awaiting Kidney Transplantation

Transpl Int. 2023 Aug 22:36:11771. doi: 10.3389/ti.2023.11771. eCollection 2023.

Authors

Daqiang Zhao^#^{1

2}, Zhiliang Guo^#¹, Guangyuan Zhao^{1

2}, Rula Sa¹, Lan Zhu^{1

2}, Gang Chen^{1

2}

Affiliations

¹ Institution of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, Wuhan, China.

^# Contributed equally.

No abstract available

Keywords: anti-CD38 monoclonal antibody; daratumumab; desensitization; plasma cells; presensitized kidney transplantation.

MeSH terms

Antibodies, Monoclonal* / therapeutic use
Humans
Kidney Transplantation*

Substances

daratumumab
Antibodies, Monoclonal

Grants and funding

This study was supported by the Tongji Hospital Clinical Research Flagship Program (2019CR108).