Prolonged and Controllable Release of Doxorubicin Hydrochloride from the Composite Electrospun Poly(ε-Caprolactone)/Polyvinylpyrrolidone Scaffolds

Semen Goreninskii; Apollinariya Volokhova; Anastasia Frolova; Mikhail Buldakov; Nadezhda Cherdyntseva; Evgeny Choynzonov; Evgeny Sudarev; Victor Filimonov; Sergei Tverdokhlebov; Evgeny Bolbasov

doi:10.1016/j.xphs.2023.08.025

Prolonged and Controllable Release of Doxorubicin Hydrochloride from the Composite Electrospun Poly(ε-Caprolactone)/Polyvinylpyrrolidone Scaffolds

J Pharm Sci. 2023 Nov;112(11):2752-2755. doi: 10.1016/j.xphs.2023.08.025. Epub 2023 Sep 4.

Affiliations

¹ Onconanotheranostics laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow, Russian Federation; B.P. Veinberg Research and Educational Center, Tomsk Polytechnic University, Tomsk, Russian Federation.
² B.P. Veinberg Research and Educational Center, Tomsk Polytechnic University, Tomsk, Russian Federation; Department of Translational Cellular and Molecular Biomedicine, Chemical Faculty, National Research Tomsk State University, Russian Federation.
³ Biological Institute, Tomsk State University, Tomsk, Russian Federation; Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation.
⁴ Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation.
⁵ N.M. Kizhner Research and Educational Center, Tomsk Polytechnic University, Tomsk, Russian Federation.
⁶ B.P. Veinberg Research and Educational Center, Tomsk Polytechnic University, Tomsk, Russian Federation. Electronic address: tverd@tpu.ru.
⁷ B.P. Veinberg Research and Educational Center, Tomsk Polytechnic University, Tomsk, Russian Federation; V.E. Zuev Institute of Atmospheric Optics, Siberian Branch of the Russian Academy of Sciences, Tomsk, Russian Federation. Electronic address: Ftoroplast@tpu.ru.

PMID: 37673173
DOI: 10.1016/j.xphs.2023.08.025

Abstract

Burst release, typical for the drug-loaded electrospun poly(ε-caprolactone) (PCL) scaffolds is unfavorable in case of cytostatics due to the toxic levels reached during the initial implantation period. In the present short communication, we report an unexpected ability of the composite scaffolds made of PCL and water-soluble polyvinylpyrrolidone (PVP) to provide long-term release of widely used anti-cancer drug doxorubicin hydrochloride (DOX-HCl). That effect was observed for electrospun DOX-HCl-loaded composite scaffolds based on PCL and PVP with various mass ratios (100/0, 95/5, 90/10, 75/25 and 50/50). After the morphology and water contact angle studies, it was concluded that PVP content has no effect on the average fiber diameter, while PVP content higher 10 wt. % changes the hydrophobic character of the scaffolds surface (water contact angle of 123.9 ± 3.5°) to superhydrophilic (water contact angle of 0°). Despite the dramatic change in water wettability, by high performance liquid chromatography (HPLC), it was revealed that the PVP content in the scaffolds reduces the DOX-HCl release rate under short (first hours) and long-term (during 1 month) exposure to phosphate buffer saline (PBS). These results are in good agreement with in vitro studies, in which the viability of HeLa cervical cancer cells was higher after 24 h of culture with scaffolds with high PVP content.

Keywords: Biodegradable polymer(s); Cancer chemotherapy; Controlled release; Polymeric drug delivery system(s).