The neurocircuitry of fasting-induced glucocorticoid release

Nikolai P Jaschke; Andrew Wang

doi:10.1016/j.cmet.2023.08.004

The neurocircuitry of fasting-induced glucocorticoid release

Cell Metab. 2023 Sep 5;35(9):1497-1499. doi: 10.1016/j.cmet.2023.08.004.

Authors

Nikolai P Jaschke¹, Andrew Wang²

Affiliations

¹ Division of Endocrinology, Department of Medicine III, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. Electronic address: nikolai.jaschke@uniklinikum-dresden.de.
² Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.

PMID: 37673035
DOI: 10.1016/j.cmet.2023.08.004

Abstract

Activation of the hypothalamus-pituitary-adrenal gland (HPA) axis confers adaptations to homeostatic perturbations including food scarcity. A comprehensive new study by Douglass et al. disentangled how agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus (ARC) trigger rapid HPA-axis activation in response to fasting, which is mediated by repression of a tonic, inhibitory neuro circuit.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Acclimatization*
Arcuate Nucleus of Hypothalamus
Fasting
Glucocorticoids*
Homeostasis

Substances

Glucocorticoids