Surgeon's Experience May Circumvent Operative Volume in Improving Early Outcomes After Pancreaticoduodenectomy

Muhammad A Khan; Shah Muhammad; Haider Mehdi; Abida Parveen; Uzma Soomro; Jehangir Farman Ali; Abdaal W Khan

doi:10.7759/cureus.42927

Surgeon's Experience May Circumvent Operative Volume in Improving Early Outcomes After Pancreaticoduodenectomy

Cureus. 2023 Aug 3;15(8):e42927. doi: 10.7759/cureus.42927. eCollection 2023 Aug.

Authors

Muhammad A Khan^{1

2

3}, Shah Muhammad^{1

2

3}, Haider Mehdi^{3

2}, Abida Parveen^{1

2}, Uzma Soomro^{1

2}, Jehangir Farman Ali², Abdaal W Khan^{1

2

3}

Affiliations

¹ Hepato-Pancreato-Biliary (HPB) Surgery, Sindh Institute of Urology and Transplantation, Karachi, PAK.
² General Surgery, Sindh Institute of Medical Sciences, Karachi, PAK.
³ Transplant Surgery, Sindh Institute of Urology and Transplantation, Karachi, PAK.

Abstract

Introduction Pancreaticoduodenectomy (PD) is a complex procedure with a significant proportion of postoperative complications and improving but notable mortality. PD was the prototype procedure that initiated the lingering debate about the relationship of better operative outcomes when performed at higher-volume centers. This has not translated into practice. Impediments include the absence of a universally accepted definition of a high-volume center among others. Contrary evidence suggests equivalent outcomes for PD at low-volume centers when performed by experienced hepatobiliary surgeons. We reviewed our perioperative outcomes for PD from an earlier period as a low-volume center with an experienced team. Methods A longitudinal study of all PDs completed in our department between 2012 and 2017 was performed. Results A total of 28 PD were performed during this period. Pylorus-preserving PD was performed in 23 patients and classical PD in the remaining. A separate Roux-en-Y loop was used for high-risk pancreatic anastomosis in six cases. The mean patient age was 49.3±12.4 years. The male-to-female ratio was 1.3:1. Preoperative drainage procedures were carried out in 19 patients. The mean serum total bilirubin level was 3.98(±4.5) mg/dL. There was no 90-day mortality. Postoperative complications included wound infection in 10 (36.7%) and respiratory complications in 10 (36.7%) patients. Postoperative bleeding requiring intervention occurred in one patient, and two patients had an anastomotic leak (one pancreatojejunostomy (PJ) and one gastrojejunostomy (GJ)). Delayed gastric emptying (DGE) was noted in three (10.7%) patients. The mean length of hospital stay was 14±7 days. The median overall survival (OS) was 84 months. Conclusion Comparable early outcomes can be achieved at low-volume centers for patients undergoing PD with an experienced team, optimal patient selection, and the ability to rescue for complications.

Keywords: complications; delayed gastric emptying; low-volume center; overall survival (os); pancreaticoduodenectomy; pancreaticoduodenectomy (pd); postoperative pancreatic fistula; pylorus-preserving pancreaticoduodenectomy; short-term outcome.