Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Zhenyu Zhang; Minnan Chen; Wenjing Zhan; Yuechun Chen; Tongtong Wang; Zhonghua Chen; Yifei Fu; Gang Zhao; Dong Mao; Jingjing Ruan; Feng-Lai Yuan

doi:10.1038/s41420-023-01624-6

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Cell Death Discov. 2023 Sep 4;9(1):330. doi: 10.1038/s41420-023-01624-6.

Authors

Zhenyu Zhang^#¹, Minnan Chen^#², Wenjing Zhan^#³, Yuechun Chen¹, Tongtong Wang¹, Zhonghua Chen¹, Yifei Fu¹, Gang Zhao⁴, Dong Mao⁵, Jingjing Ruan^{6

7}, Feng-Lai Yuan⁸

Affiliations

¹ Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China.
² Nantong First People's Hospital, Nantong, 226001, China.
³ The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, 230032, China.
⁴ Orthopaedic Institute, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214062, China.
⁵ Orthopaedic Institute, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214062, China. maodong3344@suda.edu.cn.
⁶ Nantong First People's Hospital, Nantong, 226001, China. ruan-jingjing@hotmail.com.
⁷ Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China. ruan-jingjing@hotmail.com.
⁸ Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. bjjq88@jiangnan.edu.cn.

^# Contributed equally.

Abstract

Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca²⁺ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca²⁺‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.

Publication types

Review