Mild traumatic brain injury as a cause of adult growth hormone deficiency: Diagnosis and treatment

Best Pract Res Clin Endocrinol Metab. 2023 Dec;37(6):101818. doi: 10.1016/j.beem.2023.101818. Epub 2023 Aug 24.

Abstract

In recent years, mild traumatic brain injury (mTBI) has been recognized as a cause of acquired growth hormone deficiency (AGHD) and is likely much more prevalent than previous estimates. There is great overlap between persistent symptoms following mTBI and those of AGHD and it is possible that these persistent symptoms of mTBI are, at least in part, due to or aggravated by AGHD. This article reviews the current literature of AGHD following mTBI, and proposes practice recommendations for the screening, diagnosis, and management of patients with AGHD following mTBI.

Keywords: acquired growth hormone deficiency; growth hormone replacement therapy; mild traumatic brain injury; traumatic brain injury.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Concussion* / complications
  • Brain Concussion* / diagnosis
  • Brain Concussion* / therapy
  • Dwarfism, Pituitary*
  • Growth Hormone
  • Humans

Substances

  • Growth Hormone