Oral candidiasis in patients with kidney transplantation in Iran: prevalence and antifungal susceptibility pattern

Future Microbiol. 2023 Jul:18:715-722. doi: 10.2217/fmb-2022-0179. Epub 2023 Sep 4.

Abstract

Aim: This study aimed to identify Candida species recovered from the oral cavity of patients with kidney transplantation. Materials & methods: Two swabs were taken from the oral cavities of 40 patients before and after transplantation, cultured on Sabouraud dextrose agar, and yeasts identified. Antifungal drug susceptibility testing was performed with fluconazole and itraconazole. Results: Candida glabrata was the most frequently isolated species in patients, followed by Candida albicans and Rhodotorula. C. glabrata isolates from patients before transplantation were resistant to fluconazole, whereas C. albicans was fluconazole-resistant both before and after transplantation. Conclusion: The importance of non-albicans Candida species in the oral cavity of patients sheds light on performing antifungal tests for achieving the best outcome to prevent therapeutic failure.

Keywords: Candida species; antifungal drug susceptibility; kidney transplant; molecular identification; oral candidiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Candida
  • Candida albicans
  • Candida glabrata
  • Candidiasis, Oral* / drug therapy
  • Candidiasis, Oral* / epidemiology
  • Fluconazole / pharmacology
  • Fluconazole / therapeutic use
  • Humans
  • Iran / epidemiology
  • Kidney Transplantation* / adverse effects
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis*
  • Prevalence

Substances

  • Antifungal Agents
  • Fluconazole